ArthroSoothe Supreme contains all of the ingredients found in our standard ArthroSoothe, plus the revolutionary tissue regeneration factor or TRF (as Cyplexinol™ PRO). TRF is a bone-derived complex containing collagen and biologically active proteins known as Body/Bone Morphogenetic Proteins (BMPs). BMPs are the components that activate the cartilage-forming process, which is necessary for joint integrity and regeneration. They also help suppress inflammatory cytokines, leading to joint and cartilage homeostasis. TRF works synergistically with glucosamine sulfate and helps to make ArthroSoothe Supreme an ideal choice when more involved attention to cartilage health is desired.